Best answer: Which antipsychotics cause NMS?

The primary trigger of NMS is dopamine receptor blockade and the standard causative agent is an antipsychotic. Potent typical neuroleptics such as haloperidol, fluphenazine, chlorpromazine, trifluoperazine, and prochlorperazine have been most frequently associated with NMS and thought to confer the greatest risk.

What antipsychotics cause neuroleptic malignant syndrome?

Any antipsychotic drug can cause NMS.

Doctors call the newer antipsychotic drugs “atypical antipsychotics.” They include:

  • Aripiprazole (Abilify)
  • Asenapine (Saphris)
  • Brexpiprazole (Rexulti)
  • Cariprazine (Vraylar)
  • Clozapine (Clozaril)
  • Iloperidone (Fanapt)
  • Olanzapine (Zyprexa)
  • Paliperidone (Invega)

Do typical antipsychotics cause NMS?

Although atypical antipsychotics were initially considered to carry no risk of NMS, reports have accumulated over time implicating them in NMS causation. Almost all atypical antipsychotics have been reported to be associated with NMS.

What psych meds cause NMS?

Atypical antipsychotic drugs that may cause NMS include the following:

  • Olanzapine.
  • Risperidone.
  • Paliperidone.
  • Aripiprazole.
  • Ziprasidone.
  • Amisulpride.
  • Quetiapine.

Do second generation antipsychotics cause NMS?

Background: Neuroleptic malignant syndrome (NMS) is a rare, severe, idiosyncratic adverse reaction to antipsychotics. Second-generation antipsychotics (SGAs) were originally assumed to be free from the risk of causing NMS, however several cases of NMS induced by SGAs (SGA-NMS) have been reported.

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What is NMS neuroleptic malignant syndrome?

INTRODUCTION Neuroleptic malignant syndrome (NMS) is a life-threatening neurologic emergency associated with the use of antipsychotic (neuroleptic) agents and characterized by a distinctive clinical syndrome of mental status change, rigidity, fever, and dysautonomia.

Can Abilify cause neuroleptic malignant syndrome?

A potentially fatal symptom complex sometimes referred to as neuroleptic malignant syndrome (NMS) has been reported in association with administration of antipsychotic drugs, including aripiprazole. Rare cases of NMS occurred during aripiprazole treatment in the worldwide clinical database.

What are the symptoms of NMS?

Symptoms of neuroleptic malignant syndrome usually include very high fever (102 to 104 degrees F), irregular pulse, accelerated heartbeat (tachycardia), increased rate of respiration (tachypnea), muscle rigidity, altered mental status, autonomic nervous system dysfunction resulting in high or low blood pressure, …

Can Ritalin cause NMS?

It is possible that patients who have a propensity to develop NMS with antipsychotic medication are also likely to develop NMS with methylphenidate. Typically, NMS is caused by blockade of dopaminergic receptors.

Can lithium cause NMS?

Lithium is a first-line mood stabilizer used in the treatment and prophylaxis of bipolar disorder. There are several case reports of lithium-associated NMS, but only in combination with antipsychotics. Therefore, the possibility of NMS being secondary to the antipsychotics could not be ruled out in those cases.

Can NMS cause brain damage?

Neuroleptic malignant syndrome (NMS) is a rare, but potentially lethal neurological emergency. Fifty percent of traumatic brain injury (TBI) patients will have emotional disorders and post-traumatic agitations.

Which of the following patients is most likely to have neuroleptic malignant syndrome?

Neuroleptic malignant syndrome has been reported to be more common in males, although that most likely reflects greater neuroleptic usage rather than greater susceptibility. The male-to-female ratio is 2:1.

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