Is sertraline hard on the kidneys?

For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. This drug may also decrease your kidney function, making your kidney disease worse.

Is sertraline safe for kidneys?

Meaning Sertraline may not be an effective treatment for major depressive disorder in patients with non–dialysis-dependent chronic kidney disease. Importance Major depressive disorder (MDD) is prevalent among patients with chronic kidney disease (CKD) and is associated with morbidity and mortality.

Which antidepressant is safe for kidneys?

Table 2

Medication class and dosing in normal eGFR Dosing in CKD and ESRD
Citalopram 20–40 mg/day, single dose Initial dose 10 mg/day; active metabolite. Not recommended for eGFR <20 ml/min
Escitalopram 10–20 mg/day, single dose Use with caution in severe renal impairment
Dopamine/norepinephrine reuptake inhibitors

Can you take Zoloft with kidney disease?

Sertraline may not be an effective treatment for major depressive disorder in patients with non–dialysis-dependent chronic kidney disease.

Is Serotonin bad for kidneys?

Serotonin (5HT) has significant effects on renal metabolism and glomerular function and is a potent renal vasoconstrictor.

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Are antidepressants hard on kidneys?

A: Any medication, if taken without consultation with your physician, can cause kidney damage. It is frequently combinations of medication, both prescribed and over the counter that cause kidney damage.

Does sertraline affect creatinine levels?

We found no relationship between maximum sertraline dose, age, and changes in routine blood chemistry results with the exception of a small (0.5%) contribution of maximum sertraline dose to variance in serum creatinine levels. Sertraline therapy was not noted to cause any significant changes in serum sodium levels.

What are the side effects of sertraline?

Sertraline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • diarrhea.
  • constipation.
  • vomiting.
  • difficulty falling asleep or staying asleep.
  • dry mouth.
  • heartburn.
  • loss of appetite.

Can depression affect your kidneys?

Summary: Depression is associated with an increased risk of developing kidney failure in the future, according to a new study. Approximately 10 percent of the US population will suffer from depression at some point during their lifetime.

Can sertraline damage your liver?

Rare instances of acute liver failure have been attributed to sertraline therapy. Rechallenge usually results in recurrence of liver injury and should be avoided. Persons with intolerance to sertraline may have similar reactions to other SSRIs and careful monitoring is warranted if other such agents are used.

Is sertraline safe for dialysis patients?

Before administering the medication, one should consider benefits and possible side effects, which are particularly significant in the treatment of ESRD patients; this could help to optimize clinical outcomes. Sertraline seems to be safe in the HD population when provided in proper doses.

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Is Prozac hard on kidneys?

Fluoxetine (applies to Prozac) renal dysfunction

Minor Potential Hazard, Low plausibility. Fluoxetine is primarily metabolized by the liver. All but one metabolites are inactive, and they are excreted by the kidney. The clearance of norfluoxetine, the active metabolite, is not dependent on renal function.