Sertraline is metabolized at least in part by the liver, mainly via the cytochrome P450 system and PYP 2D6 and 2B6 which can cause drug-drug interactions.
How is sertraline metabolized?
Sertraline is heavily metabolized in the liver and has one major active metabolite. It undergoes N-demethylation to form N-desmethylsertraline, which is much less potent in its pharmacological activity than sertraline.
Where is sertraline metabolized?
ZOLOFT is extensively metabolized by the liver. In patients with chronic mild liver impairment, sertraline clearance was reduced, resulting in increased AUC, Cmax and elimination half-life. The effects of sertraline in patients with moderate and severe hepatic impairment have not been studied.
What antidepressant is not metabolized in the liver?
The antidepressants that seem to have the least potential for hepatotoxicity are citalopram, escitalopram, paroxetine, and fluvoxamine. Cross-toxicity has been described, mainly for tricyclic and tetracyclic antidepressants.
Which antidepressant is safe in liver disease?
Choosing the right antidepressant for these patients can be difficult since clinicians must take into account the patients reduced liver function and concomitant medications. For patients with CLD and hepatitis C, selective serotonin reuptake inhibitors (SSRIs) appear to be the safest class of antidepressants.
Can sertraline damage your kidneys?
For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. This drug may also decrease your kidney function, making your kidney disease worse.
Can Zoloft cause elevated liver enzymes?
Hepatotoxicity is a rare side effect occurring in 0.8% of study patients on Sertraline. Increase in enzyme levels usually develop in the first one to nine weeks of treatment and usually respond to discontinuation of the medication (3).
What enzymes metabolize sertraline?
Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study.
How can I get Zoloft out of my system?
One method that people use to quit SSRIs is a medication taper. If you were to taper sertraline, you would gradually reduce your dose over the course of several weeks or months.
- Exercise. Getting about 45 minutes of moderate activity three times a week can improve mood and reduce stress.
- Sleep. …
How long does it take for zoloft to be digested?
Sertraline is absorbed slowly when taken orally, achieving its maximal concentration in the plasma 4 to 6 hours after ingestion.
Can paroxetine damage the liver?
Paroxetine, fluoxetine, fluvoxamine, citalopram, mirtazapine and venlafaxine are associated with reversible liver injury upon discontinuation of the agent. Patient cases of hepatotoxicity involving the use of nefazodone, trazodone, duloxetine, bupropion, and sertraline are linked to causing death in its users.
Do antidepressants damage liver?
Some antidepressants can damage your liver over time, including monoamine oxidase (MAO) inhibitors, tricyclic or tetracyclic antidepressants, bupropion, duloxetine and agomelatine. Antidepressant drugs with a lower risk of liver damage include citalopram, escitalopram, paroxetine and fluvoxamine.
Are antidepressants metabolized by the liver?
The liver is the organ by which the majority of substances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs.
Are SSRIs safe in liver disease?
Selective serotonin reuptake inhibitors (SSRIs) and selective noradrenaline reuptake inhibitors (SNRIs) are effective and generally safe in both CLD and OLT patients.
What meds are bad for liver?
The 10 Worst Medications for Your Liver
- 1) Acetaminophen (Tylenol) …
- 2) Amoxicillin/clavulanate (Augmentin) …
- 3) Diclofenac (Voltaren, Cambia) …
- 4) Amiodarone (Cordarone, Pacerone) …
- 5) Allopurinol (Zyloprim) …
- 6) Anti-seizure medications. …
- 7) Isoniazid. …
- 8) Azathioprine (Imuran)
What are the side effects of sertraline?
Sertraline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- difficulty falling asleep or staying asleep.
- dry mouth.
- loss of appetite.