Trazodone is not a medication that is primarily designed to produce sleep (a sedative or hypnotic medication). Trazodone was developed as an antidepressant medication.
What is trazodone classified?
Trazodone belongs to the antidepressant drug class — more specifically, it is classified as an atypical antidepressant and a serotonin modulator.
What contributes to trazodone hypnotic effects?
The blocking of the 5-HT2A, histamine H1, and alpha receptors is thought to produce the hypnotic effect reported for low doses of trazodone (25–100mg). At these low doses, trazodone induces and maintains sleep without causing daytime drowsiness or tolerance, mainly because of its short half-life (3–6 hours).
What does trazodone do to the brain?
How does trazodone work? Serotonin and noradrenaline are chemicals in the brain that help improve your mood. When your levels are low, you can get depressed. Trazodone helps increase your levels of serotonin and noradrenaline so you feel better.
Is trazodone considered a benzodiazepine?
Desyrel (trazodone) is also used to treat depression. Xanax is also used to treat panic attacks. Desyrel (trazodone) and Xanax belong to different drug classes. Desyrel (trazodone) is an antidepressant and Xanax is a benzodiazepine.
Does trazodone relax muscles?
Trazodone is a drug that is associated with the unique ability to cause persistent drug-induced inhibition of genital smooth muscle contraction and persistent drug-induced enhancement of genital smooth muscle relaxation.
Is trazodone considered a narcotic?
Even though the antidepressant/sleep aid is not classified as a narcotic, it can cause false positives on drug tests. According to the National Center for Biotechnology Information, “The trazodone metabolite meta-Chlorophenylpiperazine [m-CPP] can cause false-positive urine amphetamine immunoassay results.…
Does trazodone affect sleep architecture?
Because of its sedation, trazodone is currently more likely to be used as a hypnotic than as an antidepressant. PSG studies indicate that trazodone decreases sleep latency, may improve sleep continuity, increases SWS, but does not affect REM sleep.
Which is better for sleep trazodone or melatonin?
Conclusions: This study demonstrated that both melatonin and trazodone would improve SQ in outpatients with MDD after 8 weeks of treatment with sertraline. However, melatonin created greater reduction in SL than trazodone did after the first 4 weeks of use.
Does trazodone lower dopamine?
Trazodone reduces levels of neurotransmitters associated with arousal effects, such as serotonin, noradrenaline, dopamine, acetylcholine, and histamine.
Is trazodone a strong sleeping pill?
Because of the chemical composition of trazodone, it has been found to have mild sedating effects, and it is less effective than other antidepressants for the treatment of depression. Therefore, trazodone has found greater utility as a sleep aid than it has as an antidepressant medication.
Does trazodone affect memory?
Trazodone produced small but significant impairments of short-term memory, verbal learning, equilibrium, and arm muscle endurance across time points.
What is better than trazodone for sleep?
The study found Ambien to be more effective than trazodone. The American Academy of Sleep Medicine Clinical guidelines recommend the following: Trazodone: “We suggest that clinicians not use trazodone as a treatment for sleep onset or sleep maintenance insomnia (versus no treatment) in adults.”
Is trazodone safer than Xanax?
Xanax and trazodone don’t impact the same pathways in the body. Xanax affects the central nervous system and trazodone impacts chemicals in the brain, so this reduces the risk of dangerous interactions with Xanax and trazodone together.
Is trazodone 50 mg like Xanax?
Xanax is similar to trazodone in that it may cause side effects such as feeling tired and drowsy. When this occurs during the day, it can affect your day-to-day activities. However, unlike trazodone, Xanax and other benzodiazepine drugs can be addictive, even if you’ve been using them as directed.
Is trazodone an SSRI or SNRI?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) that has been available for the treatment of MDD with or without anxiety since the early 1970s .