The most efficacious antidepressants for the treatment of neuropathic pain appear to be the tertiary-amine TCAs (amitriptyline, doxepin, imipramine), venlafaxine, bupropion, and duloxetine. These appear to be closely followed in efficacy by the secondary-amine TCAs (desipramine, nortriptyline).
Can antidepressants cure nerve pain?
SSRIs , which include drugs such as paroxetine (Paxil) and fluoxetine (Sarafem, Prozac), may help relieve certain types of pain, but there’s a lack of evidence that they help alleviate nerve pain.
What is the strongest drug for nerve pain?
Tramadol is a powerful painkiller related to morphine that can be used to treat neuropathic pain that does not respond to other treatments your GP can prescribe. Like all opioids, tramadol can be addictive if it’s taken for a long time.
Can Paxil be used for nerve pain?
Paxil (paroxetine) has been used for some time now for the treatment of pain conditions. It is not specific in addressing pain, but can relieve pain caused by such conditions as nerve diseases, fibromyalgia, and other pain problems.
Does Wellbutrin help with nerve pain?
The results of this open-label trial offer preliminary evidence that SR bupropion at a dosage of 150 to 300 mg/day may be clinically effective for the treatment of neuropathic pain. Among the patients treated in the trial, two thirds reported that their pain was improved or much improved with bupropion.
Is tramadol used for nerve pain?
Evidence-Based Answer. Tramadol is an effective treatment for neuropathic pain. One out of four patients who take the medication achieves at least 50 percent pain relief.
Is Cymbalta used for nerve pain?
The U.S. Food and Drug Administration (FDA) has approved the antidepressant Cymbalta® (duloxetine HCl; pronounced SIM-BALL-TA), judging it safe and effective for the management of diabetic peripheral neuropathic pain, a symptom of nerve damage that affects up to 5 million Americans, Eli Lilly and Company (NYSE: LLY) …
How do neurologists treat nerve pain?
Multimodal therapy (including medicines, physical therapy, psychological counseling and sometimes surgery) is usually required to treat neuropathic pain. Medicines commonly prescribed for neuropathic pain include anti-seizure drugs such as: Gabapentin (Neurontin®). Pregabalin (Lyrica®).
Does zoloft help nerve pain?
There is limited evidence that newer antidepressants, called selective serotonin reuptake inhibitors (SSRIs), may also provide neuropathic pain relief. Researchers say more studies are needed before they can be recommended for this use. SSRIs include Prozac, Celexa, Luvox, Zoloft, and Paxil.
Does doxepin help with nerve pain?
In literature and research studies, doxepin has proven to be an effective analgesic in treating neuropathic pain.
Does Trazodone help with nerve pain?
Although 8 patients (25.8%) discontinued the drug because of side effects, these were relatively minor (dizziness, headache, insomnia). Low-dose trazodone is recommended as an effective treatment option for painful diabetic neuropathy.
Are Cymbalta and Wellbutrin similar?
Cymbalta (duloxetine) and Wellbutrin (bupropion) are antidepressants. Cymbalta and Wellbutrin belong to different drug classes. Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), and Wellbutrin belongs to the aminoketone class.
Is Effexor good for nerve pain?
Conclusion: In conclusion, venlafaxine is a safe and well-tolerated analgesic drug for the symptomatic treatment of neuropathic pain, and there is limited evidence that high-dose venlafaxine (150 mg/day) can be even more beneficial.