Among SSRIs, those with the higher degree of serotonin reuptake inhibition, fluoxetine, paroxetine, and sertraline are more frequently associated with abnormal bleeding (2). SSRI use is associated with doubled risk of upper GI bleeding; bleeding at other sites has been less commonly reported (1).
Does zoloft make you bleed more?
That’s because selective serotonin reuptake inhibitors (SSRIs), one of the most widely prescribed classes of drugs to treat depression, have been found to carry a significantly increased risk of internal bleeding. Trade names of drugs in the SSRI class include Prozac, Celexa, Paxil and Zoloft, among others.
Can antidepressants make you bleed more?
Because antidepressants influence blood serotonin levels, their use may be associated with an increased risk of abnormal bleeding.
Is Zoloft a blood thinner?
The drugs used to treat depression by affecting the brain’s use of the chemical serotonin — Prozac, Paxil, Zoloft — also tend to reduce the abnormalities in heart rhythm and blood clotting. For cardiac patients, these antidepressants may act primarily as blood thinners, a complicated form of baby aspirin.
Can Zoloft cause blood clotting?
Depression and the use of antidepressants can increase the risk of life-threatening blood clots forming in vital veins, a first-of-its-kind study has found.
Does Zoloft affect your period?
An antidepressant, such as Prozac (fluoxetine) or Zoloft (sertraline), can be an effective way to relieve symptoms of depression—but it’s not right for everyone. In addition to possible side effects, some antidepressants can even cause your period to be late or delayed.
Can sertraline cause spotting?
As a result, SSRI and sertraline increase the risk of bleeding. Sertraline and other SSRIs inhibit serotonin reuptake into platelets, affecting normal platelet clustering, which can result in bleeding, purpura, petechiae, ecchymosis.
Can Zoloft cause nosebleeds?
Side Effects in Children and Adolescents
Abnormal or agitated muscle movements. Frequent urination. Heavy menstrual period. Nosebleeds.
How do SSRIs increase bleeding?
SSRIs selectively inhibit presynaptic serotonin (5-HT) reuptake. Generally, it is supposed that SSRIs increase the risk of abnormal bleeding events by inhibiting the uptake of serotonin into platelets, thus leading to impairment in the platelet hemostatic response.
Does paroxetine cause bleeding?
Rare/serious side effects
SSRI antidepressants including paroxetine may increase the risk of bleeding events. Combined use of aspirin, nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen), warfarin, and other anti-coagulants may increase this risk.
Why is Zoloft bad for you?
Taking Zoloft may put you at risk for a rare, possibly life-threatening condition called serotonin syndrome. This risk is higher if you are also taking other serotonin-related medications like triptans (a common migraine medication), tricyclic antidepressants, or the pain medication Ultram (tramadol).
What are the most common side effects of Zoloft?
Nausea, dizziness, drowsiness, dry mouth, loss of appetite, increased sweating, diarrhea, upset stomach, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Is it better to take Zoloft in the morning or at night?
Typically, your doctor will recommend that you take your prescribed dose of sertraline once a day, either in the morning or evening. If sertraline makes you drowsy, your doctor may suggest that you take it at bedtime. It’s important to be consistent when and how you take the medication.
Does serotonin cause blood clots?
Elevated platelet serotonin levels promote clotting, which may be a potential underlying mechanism linking depression with CAD.