Which antidepressant has least anticholinergic effects?
SSRIs are the initial antidepressants of choice for uncomplicated depression because of their minimal anticholinergic effects. They have the advantage of ease of dosing and low toxicity in overdose.
Which SSRI has most anticholinergic side effects?
A comparison of ED(50) values showed that the ratio of anticholinergic effect to antidepressant activity was fluvoxamine, >3.2; paroxetine, 2.1-2.6; clomipramine, <0.8. These results suggest that paroxetine may induce fewer adverse anticholinergic effects than clomipramine, but more than fluvoxamine.
Is sertraline an anticholinergic?
Sertraline is generally well tolerated in elderly patients with major depressive disorder and lacks the marked anticholinergic effects that characterise the adverse event profiles of tricyclic antidepressants (TCAs).
What are anticholinergic effects of antidepressants?
Summary. The anticholinergic actions of antidepressants can have undesirable effects that affect patient’ well-being. These effects can be peripheral or central in origin. The most frequently occurring anticholinergic effects are sedation, psychomotor and memory impairment, dry mouth and blurred vision.
Is doxepin an anticholinergic?
Historically, doxepin has been used to treat depression and anxiety disorders, with its sedative effects improving disrupted sleep. At antidepressant doses (25-300 mg per day), however, doxepin possesses significant anticholinergic and antinoradrenergic properties, leading to dose-limiting side effects.
Are SSRI’s anticholinergic?
Antidepressant alternatives that don’t increase dementia risk include SSRI antidepressants like escitalopram and sertraline, that don’t have strong anticholinergic properties.
Is Paxil anticholinergic?
Because Paxil has anticholinergic properties, some health experts fear it may pose a problem for older patients.
Is citalopram a anticholinergic?
Unlike the tricyclic antidepressants, citalopram has minimal anticholinergic effects. Mild and transient nausea, with or without vomiting, is the most frequent adverse effect–occurring in 20% of patients–and increased perspiration, headache, dry mouth, tremor and insomnia are experienced by 15 to 18% of patients.
Is Claritin anticholinergic?
Second- and third-generation antihistamines, including brands such as Claritin, Zyrtec and Allegra, are not anticholinergics. But talk to your doctor before switching to a new drug.
Is Wellbutrin an anticholinergic antidepressant?
Other medications with very low anticholinergic effects are also commonly prescribed for depression. These include serotonin and norepinephrine reuptake inhibitors (SNRIs), such as desvenlafaxine (Pristiq), and norepinephrine and dopamine reuptake inhibitors (NDRIs), such as bupropion (Wellbutrin).
Is Cymbalta a anticholinergic?
Additionally, SNRI drugs like duloxetine or venlafaxine and atypical antidepressants like bupropion have few anticholinergic effects and are possible alternatives.
Is Aricept an anticholinergic?
These medications, such as donepezil (Aricept) work by inhibiting the breakdown of acetylcholine, which sends signals in the nervous system. By contrast, anticholinergics — such as diphenhydramine (Benadryl) and oxybutynin (Ditopan) — block the action of acetylcholine.
Is Lexapro anticholinergic?
Unlike tricyclic antidepressants, including amitriptyline or doxepin, medications like Wellbutrin and Lexapro have low anticholinergic effects. That means they are less likely to lead to side effects like memory problems and confusion.
Is Zyprexa anticholinergic?
However, evidence from ex vivo binding, in vivo binding, and in vivo function in animals suggests that olanzapine has minimal anticholinergic effects.
Is Remeron anticholinergic?
Common anticholinergic drugs include Benadryl, Dimetapp, Sinequan (doxepin), Paxil (paroxetine), Desyrel (trazodone), Remeron (mirtazapine), Enablex (darifenacin), Toviaz (fesoterodine), Urispas (flavoxate), Ditropan (oxybutynin).